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EDITORIAL INFORMATION

Our understanding of human genome evolution has improved dramatically over the last decade, influenced both by technological advances and directed genome mapping programmes. This volume brings together, for the first time, data concerning the evolution of genes, multigene families and non-genic sequences in the human genome and provides a comprehensive review of this rapidly changing field. Human Genome Evolution also considers specific areas of the genome, such as the sex chromosomes, which have been subjected to unusual evolutionary forces as well as covering more general topics, including the evolution of human proteins by exon shuffling and the use of genetic polymorphisms to study human evolution.

(Extracted from the back cover).

GENERAL TABLE OF CONTENTS

-Contributors.

-Abbreviations.

-Preface.

-Mutational processes in pathology and evolution.

-Evolution of human proteins by exon-shuffling.

-Evolution of the HLA complex.

-Evolution of the G-protein-coupled receptor superfamily.

-Evolution of centromeric alpha satellite DNA: molecular organization within and between human and primate chromosomes.

-Telomeres, subterminal sequences, variation and turnover.

-Tandemly repeated minisatellites: generating human genetic diversity via recombinational mechanisms.

-Microsatellites and other simple sequences in the evolution of the human genome.

-Evolution of Alu retroposons.

-Human sex chromosome evolution.

-Mitochondrial DNA variation and human evolution.

-Y chromosome sequences as a tool for studying human evolution.

OUR REVIEW

The research on the human genome provides more and more revealing results. Within very few years, our knowledge about it has increased in a spectacular way.

This volume gathers works of a high scientific value, as they have been written by active researchers who have oriented their efforts to key areas in the understanding of human genome evolution. This makes this book into a very interesting one for those who work in fields where data on the human genome are needed.

The book is of a technical character, aimed at specialists, and explains the results of research in depth. Each chapter is accompanied by a specific bibliography.

On the whole, it constitutes a window to the latest advances in the study of the human genome, since the different works gathered in this book constitute a good panorama of the level reached in the scientific knowledge of the theme.